Transcription-independent function of Polycomb group protein PSC in cell cycle control.
Science
; 336(6082): 744-7, 2012 May 11.
Article
de En
| MEDLINE
| ID: mdl-22491092
ABSTRACT
Polycomb group (PcG) proteins control development and cell proliferation through chromatin-mediated transcriptional repression. We describe a transcription-independent function for PcG protein Posterior sex combs (PSC) in regulating the destruction of cyclin B (CYC-B). A substantial portion of PSC was found outside canonical PcG complexes, instead associated with CYC-B and the anaphase-promoting complex (APC). Cell-based experiments and reconstituted reactions established that PSC and Lemming (LMG, also called APC11) associate and ubiquitylate CYC-B cooperatively, marking it for proteosomal degradation. Thus, PSC appears to mediate both developmental gene silencing and posttranslational control of mitosis. Direct regulation of cell cycle progression might be a crucial part of the PcG system's function in development and cancer.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cycline B
/
Protéines de Drosophila
/
Protéines de liaison à l'ADN
/
Points de contrôle du cycle cellulaire
/
Mitose
Limites:
Animals
Langue:
En
Journal:
Science
Année:
2012
Type de document:
Article
Pays d'affiliation:
Pays-Bas