Homocysteine as a potential biochemical marker for depression in elderly stroke survivors.
Food Nutr Res
; 562012.
Article
de En
| MEDLINE
| ID: mdl-22509143
ABSTRACT
BACKGROUND:
Elderly stroke survivors have been reported to be at risk of malnutrition and depression. Vitamin B-related metabolites such as methylmalonic acid and homocysteine have been implicated in depression.OBJECTIVE:
We conducted a study exploring the relationship between homocysteine and post-stroke depression.DESIGN:
THREE METHODOLOGIES WERE USED Observational cohort study of elderly Swedish patients (n=149) 1.5 years post-stroke, assessed using Diagnostic and Statistical Manual of Mental Disorders, Montgomery Åsberg Depression Rating Scale and serum blood levels of methylmalonic acid and homocysteine.RESULTS:
Homocysteine significantly correlated with depressive symptomatology in stroke survivors (ß=0.18*). Individuals with abnormal levels of methylmalonic acid and homocysteine were almost twice more likely to show depressive symptomatology than those with normal levels (depressive symptoms 22%; no depressive symptoms 12%). Comparison of methylmalonic acid and homocysteine levels with literature data showed fewer stroke survivors had vitamin deficiency than did reference individuals (normal range 66%; elevated 34%).CONCLUSIONS:
Homocysteine is significantly associated with depressive symptomatology in elderly Swedish stroke survivors.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Type d'étude:
Guideline
/
Observational_studies
/
Risk_factors_studies
Langue:
En
Journal:
Food Nutr Res
Année:
2012
Type de document:
Article
Pays d'affiliation:
Australie