[Castleman's disease : a rare differential diagnosis for Heerfordt's syndrome]. / M. Castleman : Eine seltene Differenzialdiagnose zum Heerfordt-Syndrom.
HNO
; 60(12): 1123-6, 2012 Dec.
Article
de De
| MEDLINE
| ID: mdl-22534680
ABSTRACT
A 50-year-old male patient demonstrated an existing left proptosis for several weeks. The patient was suffering from physical exhaustion and had lost considerable weight. Furthermore, we observed greatly enlarged parotid and submandibular glands on both sides. MRI of the neck showed multiple, sharply circumscribed lesions in the major salivary glands and both lacrimal glands as well as in the orbit. Initially we suspected Heerfordt's syndrome, a manifestation of sarcoidosis, but laboratory diagnosis could not reveal a pathological erythrocyte sedimentation rate or an increased ACE titer. After exploratory excision from the right submandibular gland, histological examination revealed Castleman's disease. Therefore, we initiated an immunomodulatory therapy with interleukin-6 receptor antagonists.Castleman's disease is one of the very rare, benign, lymphoproliferative processes that have a tendency to turn malignant. Isolated findings of Castleman's disease should be completely resected. There are no clear treatment strategies for multiple localizations of Castleman's disease. The approaches range from systemic glucocorticoid therapy with chemotherapy to immunomodulatory treatment. In contrast to isolated findings, the prognosis for multicentric occurrence is unfavorable.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Uvéoparotidite
/
Hyperplasie lymphoïde angiofolliculaire
Type d'étude:
Diagnostic_studies
/
Prognostic_studies
Limites:
Humans
/
Male
/
Middle aged
Langue:
De
Journal:
HNO
Année:
2012
Type de document:
Article