Comparative studies of gene expression and the evolution of gene regulation.
Nat Rev Genet
; 13(7): 505-16, 2012 Jun 18.
Article
de En
| MEDLINE
| ID: mdl-22705669
ABSTRACT
The hypothesis that differences in gene regulation have an important role in speciation and adaptation is more than 40 years old. With the advent of new sequencing technologies, we are able to characterize and study gene expression levels and associated regulatory mechanisms in a large number of individuals and species at an unprecedented resolution and scale. We have thus gained new insights into the evolutionary pressures that shape gene expression levels and have developed an appreciation for the relative importance of evolutionary changes in different regulatory genetic and epigenetic mechanisms. The current challenge is to link gene regulatory changes to adaptive evolution of complex phenotypes. Here we mainly focus on comparative studies in primates and how they are complemented by studies in model organisms.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Physiologie comparée
/
Primates
/
Adaptation biologique
/
Régulation de l'expression des gènes
/
Épigenèse génétique
/
Spéciation génétique
/
Évolution biologique
/
Modèles génétiques
Type d'étude:
Prognostic_studies
Limites:
Animals
Langue:
En
Journal:
Nat Rev Genet
Sujet du journal:
GENETICA
Année:
2012
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique