Mapping genetic and environmental influences on cortical surface area of pediatric twins.
Neuroscience
; 220: 169-78, 2012 Sep 18.
Article
de En
| MEDLINE
| ID: mdl-22728098
ABSTRACT
Cortical surface area has been largely overlooked in genetic studies of human brain morphometry, even though phylogenetic differences in cortical surface area between individuals are known to be influenced by differences in genetic endowment. In this study, we examined the relative contribution of genetic and environmental influences on cortical surface areas in both the native and stereotaxic spaces for a cohort of homogeneously-aged healthy pediatric twins. Bilateral hemispheric surface and all lobar surface areas except the occipital lobes in native space showed high heritable estimates, while the common environmental effect on bilateral occipital lobes reached statistical significance. The proportion of genetic variance for cortical surface areas measured in stereotaxic space was lower than that measured in native space, whereas the unique environmental influences increased. This is reasonable since whole brain volume is also known to be heritable itself and so removing that component of areal variance due to overall brain size via stereotaxic transformation will reduce the genetic proportion. These findings further suggest that cortical surface areas involved in cognitive, attention and emotional processing, as well as in creating and retaining of long-term memories are likely to be more useful for examining the relationship between genotype and behavioral phenotypes.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Taille d'organe
/
Jumeaux
/
Cortex cérébral
Limites:
Child
/
Female
/
Humans
/
Male
Langue:
En
Journal:
Neuroscience
Année:
2012
Type de document:
Article
Pays d'affiliation:
Corée du Sud