Effect of infliximab top-down therapy on weight gain in pediatric Crohns disease.
Indian Pediatr
; 49(12): 979-82, 2012 Dec.
Article
de En
| MEDLINE
| ID: mdl-22728632
ABSTRACT
This retrospective-medical-record review was conducted to evaluate effect of infliximab therapy, particularly with a top-down strategy, on the nutritional parameters of children with Crohns disease (CD). 42 patients who were diagnosed with Crohns disease at the Pediatric Gastroenterology center of a tertiary care teaching hospital and achieved remission at two months and one year after beginning of treatment were divided into four subgroups according to the treatment regimen; azathioprine group (n = 11), steroid group (n = 11), infliximab top-down group (n = 11) and step-up group (n = 9). Weight, height, and serum albumin were measured at diagnosis, and then at two months and one year after the initiation of treatment. At 2 months, the Z score increment for weight was highest in the steroid group, followed by the top-down, step-up, and azathioprine groups. At one year, the Z score increment was highest in top-down group, followed by steroid, azathioprine, and step-up group. There were no significant differences between the four groups in Z score increment for height and serum albumin during the study period. The top-down infliximab treatment resulted in superior outcome for weight gain, compared to the step-up therapy and other treatment regimens.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Agents gastro-intestinaux
/
Prise de poids
/
Maladie de Crohn
/
Anticorps monoclonaux
Type d'étude:
Observational_studies
Aspects:
Patient_preference
Limites:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Langue:
En
Journal:
Indian Pediatr
Année:
2012
Type de document:
Article