A poison center's ten-year experience with flumazenil administration to acutely poisoned adults.
J Emerg Med
; 43(4): 677-82, 2012 Oct.
Article
de En
| MEDLINE
| ID: mdl-22766408
ABSTRACT
BACKGROUND:
The frequency of seizures among acutely poisoned adults who are administered flumazenil has not been well established. STUDYOBJECTIVE:
The objectives of the study were to determine the frequency of seizures among acutely poisoned adults administered flumazenil; to identify factors associated with seizures; and to determine the mental status of subjects before and after administration of flumazenil.METHODS:
This study was a historical case series of acutely poisoned adults reported to a poison control system from 1999 to 2008. Included cases were those involving administration of flumazenil to subjects who were ≥ 18 years of age. Both genders were included. Variables collected included presence of seizure or death, exposure to a pro-convulsant drug, and mental status before and after flumazenil administration.RESULTS:
Over the 10-year period studied, 904 cases were identified that met inclusion criteria. Thirteen subjects (1.4%) developed seizures after flumazenil was administered. One death occurred. There were 293 subjects exposed to a pro-convulsant drug, and 8 of these had seizures after flumazenil administration. Development of seizures after flumazenil administration was significantly associated with exposure to a pro-convulsant drug (odds ratio 3.41; 95% confidence interval 1.13-10.72). Mental status before and after flumazenil administration was available for 546 subjects (60.3%). Of these, 291 (53.3%) became awake after administration of flumazenil.CONCLUSIONS:
Flumazenil administration to acutely poisoned adults resulted in a low frequency of seizures and death. Development of seizures was associated with exposure to a pro-convulsant drug. More than half of the subjects for whom mental status was recorded became awake after receiving flumazenil.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Crises épileptiques
/
Benzodiazépines
/
Flumazénil
/
Convulsivants
/
Hypnotiques et sédatifs
/
Antidotes
Type d'étude:
Etiology_studies
/
Prognostic_studies
Limites:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Pays/Région comme sujet:
America do norte
Langue:
En
Journal:
J Emerg Med
Sujet du journal:
MEDICINA DE EMERGENCIA
Année:
2012
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique