[Cardiac two-pore-domain potassium channels (K2P): Physiology, pharmacology, and therapeutic potential]. / Kardiale Zwei-Porendomänen-Kaliumkanäle (K2P): Physiologie, Pharmakologie und therapeutisches Potenzial.
Dtsch Med Wochenschr
; 137(33): 1654-8, 2012 Aug.
Article
de De
| MEDLINE
| ID: mdl-22875694
ABSTRACT
Uncontrolled electrical activity caused by ion channel dysfunction produces arrhythmia in the heart. Despite recent advances in pharmaceutical research and development, effective and safe pharmacological management of cardiac arrhythmia still remains an unmet medical need. The emerging family of two-pore-domain potassium (K2P) channels stabilizes the resting membrane potential and facilitates action potential repolarization. In the heart, genetic inactivation or inhibition of two-pore-domain K + (K2P) currents by class III antiarrhythmic drugs results in action potential prolongation. In particular, human K2P3.1 channels are selectively expressed in the atria and represent targets for the pharmacological management of atrial fibrillation. Furthermore, stretch-sensitive K2P2.1 channels are implicated in mechanoelectrical feedback and arrhythmogenesis. The current knowledge on function, regulation, and cardiac significance of K2P channels is summarized in this work, and potential therapeutic implications are highlighted.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Troubles du rythme cardiaque
/
Canaux potassiques à pores à domaines en tandem
/
Électrocardiographie
Limites:
Animals
/
Humans
Langue:
De
Journal:
Dtsch Med Wochenschr
Année:
2012
Type de document:
Article