[Proton pump inhibitors in gastro-oesophageal reflux disease: what is the further step?]. / Reflux gastro-œsophagien : comment progresser au-delà des inhibiteurs de la pompe à protons ?

ABSTRACT

Optimisation of proton pump inhibitors use may improve reflux symptoms in 20-25% of the patients. Pathological gastro-oesophageal reflux should be documented in a patient with refractory reflux symptoms using upper endoscopy and/or pH testing. While on proton pump inhibitors twice daily, persistent symptoms are not related to gastro-oesophageal refluxdisease(GERD) in 50% of the patients. The new anti-reflux compounds have yet a limited efficacy and side effects that currently limit their development.