Variants on ESR1 and their association with prostate cancer risk: a meta-analysis.
Asian Pac J Cancer Prev
; 13(8): 3931-6, 2012.
Article
de En
| MEDLINE
| ID: mdl-23098495
ABSTRACT
BACKGROUND:
Epidemiological studies evaluating the association of two variants rs9340799 and rs2234693 on estrogen receptor 1 (ESR1) with prostate risk have generated inconsistent results.METHODS:
A meta-analysis was here conducted to systematically evaluate the relationship of these two variants with prostate cancer susceptibility.RESULTS:
For rs9340799, heterozygosity of T/C carriers showed a significant increased prostate cancer risk with a pooled odds ratio (OR) of 1.34 (95% CI = 1.06-1.69) while homozygote C/C carriers showed an increased but not statistically significant association with prostate cancer risk (pooled OR = 1.29, 95% CI = 0.94-1.79). Compared to the homozygous TT carriers, the allele C carriers showed a 31% increased risk for prostate cancer (pooled OR = 1.31, 95% CI = 1.06-1.63). No significant association between the rs2234693 and prostate cancer risk was found with the pooled OR of 1.15 (95% CI = 0.97-1.39, T/C and C/C vs. T/T) under the dominant genetic model. Compared to the homozygote T/T carriers, the heterozygous T/C carriers did not show any significantly different risk of prostate cancer (pooled OR = 1.13, 95% CI = 0.94-1.36) and the homozygous C/C carriers also did not show a significant change for prostate cancer risk compared to the wide-type T/T carriers (pooled OR = 1.26, 95% CI = 0.98-1.62).CONCLUSIONS:
These data suggested that variant rs9340799, but not rs2234693, on ESR1 confers an elevated risk of prostate cancer.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Polymorphisme génétique
/
Tumeurs de la prostate
/
Prédisposition génétique à une maladie
/
Récepteur alpha des oestrogènes
Type d'étude:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Systematic_reviews
Limites:
Humans
/
Male
Langue:
En
Journal:
Asian Pac J Cancer Prev
Sujet du journal:
NEOPLASIAS
Année:
2012
Type de document:
Article
Pays d'affiliation:
Chine