A modified SILCS contraceptive diaphragm for long-term controlled release of the HIV microbicide dapivirine.
Contraception
; 88(1): 58-66, 2013 Jul.
Article
de En
| MEDLINE
| ID: mdl-23177261
ABSTRACT
BACKGROUND:
There is considerable interest in developing new multipurpose prevention technologies to address women's reproductive health needs. This study describes an innovative barrier contraceptive device--based on the SILCS diaphragm--that also provides long-term controlled release of the lead candidate anti-HIV microbicide dapivirine. STUDYDESIGN:
Diaphragm devices comprising various dapivirine-loaded polymer spring cores overmolded with a nonmedicated silicone elastomer sheath were fabricated by injection molding processes. In vitro release testing, thermal analysis and mechanical characterization were performed on the devices.RESULTS:
A diaphragm device containing a polyoxymethylene spring core loaded with 10% w/w dapivirine provided continuous and controlled release of dapivirine over a 6-month period, with a mean in vitro daily release rate of 174 mcg/day. The mechanical properties of the new diaphragm were closely matched to the SILCS diaphragm.CONCLUSIONS:
The study demonstrates proof of concept for a dapivirine-releasing diaphragm with daily release quantities potentially capable of preventing HIV transmission. In discontinuous clinical use, release of dapivirine may be readily extended over 1 or more years.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pyrimidines
/
Dispositifs contraceptifs féminins
/
Agents antiVIH
/
Transcriptase inverse du VIH
Limites:
Female
/
Humans
Langue:
En
Journal:
Contraception
Année:
2013
Type de document:
Article
Pays d'affiliation:
Royaume-Uni