Hydrometallation-asymmetric conjugate addition: application to complex molecule synthesis.
Chem Commun (Camb)
; 49(39): 4211-3, 2013 May 14.
Article
de En
| MEDLINE
| ID: mdl-23192003
ABSTRACT
Copper catalysis allows alkyl zirconium species, generated in situ from alkenes, to undergo conjugate addition reactions. A hydrometallation-catalytic asymmetric 1,4-addition was used to synthesize either enantiomer of a natural product in one step from commercially available materials. Hydrometallation-addition sequences applied to steroids containing a cross-conjugated dienone or 1,6-acceptor give highly functionalized products.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Langue:
En
Journal:
Chem Commun (Camb)
Sujet du journal:
QUIMICA
Année:
2013
Type de document:
Article
Pays d'affiliation:
Royaume-Uni