[Ischemic cholangitis in intensive care unit: favourable outcome with ursodesoxycholic acid and fenofibrate]. / Cholangite sclérosante de réanimation : évolution favorable sous acide ursodésoxycholique et fénofibrate.
Rev Med Interne
; 34(2): 110-3, 2013 Feb.
Article
de Fr
| MEDLINE
| ID: mdl-23200798
ABSTRACT
INTRODUCTION:
Ischemic cholangitis in intensive care unit is a recently reported liver disease in patients who have had a prolonged mechanical ventilation and vasopressive drug support for multiple organ deficiency. Prognosis is usually poor and the only life-saving therapy is liver transplantation despite ursodesoxycholic acid treatment. CASE REPORT We report a 63-year-old man who presented with a sclerosis cholangitis after a month in intensive care unit, effectively treated with fenofibrate and ursodesoxycholic acid. Recent reports underline fenofibrate efficacy in the treatment of primary biliary cirrhosis, especially in association with ursodesoxycholic acid. This treatment has prevented liver transplantation for our patient with a correct quality of life.CONCLUSION:
The addition of fibrate to ursodesoxycholic acid improves persistent cholestasis in sclerosing cholangitis.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Fénofibrate
/
Acide ursodésoxycholique
/
Angiocholite sclérosante
/
Soins de réanimation
Type d'étude:
Prognostic_studies
Aspects:
Patient_preference
Limites:
Humans
/
Male
/
Middle aged
Langue:
Fr
Journal:
Rev Med Interne
Année:
2013
Type de document:
Article
Pays d'affiliation:
France