Does C-reactive protein independently predict mortality in adult community-acquired bacteremia patients with known sepsis severity?
APMIS
; 121(9): 835-42, 2013 Sep.
Article
de En
| MEDLINE
| ID: mdl-23278429
ABSTRACT
We evaluated whether sepsis severity and C-reactive protein (CRP) level on admission prognostically corroborated or annulled each other in adult patients with incident community-acquired bacteremia (Funen, Denmark, 2000-2008). We used logistic regression and area under the receiver operating characteristic curve (AUC) to evaluate 30-day mortality in four models (i) age, gender, comorbidity, bacteria, and ward. (ii) Model 1 and sepsis severity. (iii) Model 1 and CRP. (iv) Model 1, sepsis severity, and CRP. Altogether, 416 of 1999 patients died within 30 days. CRP independently predicted 30-day mortality [Model 4, odds ratio (95% CIs) for 100 mg/L 1.16 (1.06-1.27)], but it did not contribute to the AUC (Model 2 vs Model 4 p = 0.31). In the 963 non-severe sepsis patients, CRP independently predicted 30-day mortality [Model 4 1.42 (1.20-1.69)] and it increased the AUC (Model 2 vs Model 4 p = 0.06), thus CRP contributed as much as sepsis severity to prognosis.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Protéine C-réactive
/
Bactériémie
/
Infections communautaires
/
Sepsie
Type d'étude:
Diagnostic_studies
/
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Adolescent
/
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
APMIS
Sujet du journal:
ALERGIA E IMUNOLOGIA
/
MICROBIOLOGIA
/
PATOLOGIA
Année:
2013
Type de document:
Article
Pays d'affiliation:
Danemark