Immunological characteristics of human mesenchymal stem cells and multipotent adult progenitor cells.
Immunol Cell Biol
; 91(1): 32-9, 2013 Jan.
Article
de En
| MEDLINE
| ID: mdl-23295415
ABSTRACT
Somatic, also termed adult, stem cells are highly attractive biomedical cell candidates because of their extensive replication potential and functional multilineage differentiation capacity. They can be used for drug and toxicity screenings in preclinical studies, as in vitro model to study differentiation or for regenerative medicine to aid in the repair of tissues or replace tissues that are lost upon disease, injury or ageing. Multipotent adult progenitor cells (MAPCs) and mesenchymal stem cells (MSCs) are two types of adult stem cells derived from bone marrow that are currently being used clinically for tissue regeneration and for their immunomodulatory and trophic effects. This review will give an overview of the phenotypic and functional differences between human MAPCs and MSCs, with a strong emphasis on their immunological characteristics. Finally, we will discuss the clinical studies in which MSCs and MAPCs are already used.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Cellules de la moelle osseuse
/
Cellules souches adultes
/
Cellules souches mésenchymateuses
Type d'étude:
Prognostic_studies
Limites:
Humans
Langue:
En
Journal:
Immunol Cell Biol
Sujet du journal:
ALERGIA E IMUNOLOGIA
Année:
2013
Type de document:
Article
Pays d'affiliation:
Belgique