Carbonic anhydrase inhibitory properties of novel sulfonamide derivatives of aminoindanes and aminotetralins.
J Enzyme Inhib Med Chem
; 29(1): 35-42, 2014 Feb.
Article
de En
| MEDLINE
| ID: mdl-23311862
ABSTRACT
Six sulfonamides derived from indanes and tetralines were synthesized. The human carbonic anhydrase isozymes hCA I and hCA II inhibition effects of the synthesized sulfonamides were determined. From these compounds, while N-(5,6-dimethoxy-2,3-dihydro-1H-inden-2-yl)methane sulfonamide showed the most potent inhibitory effect against hCA I (Ki=46 ± 5.4 µM, r(2) =0.978), N-(1,2,3,4-tetrahydronaphthalene-2-yl)methanesulfonamide was found to have the best inhibitory effect against hCA II (Ki=94 ± 7.6 µM, r(2) =0.982).
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Sulfonamides
/
Inhibiteurs de l'anhydrase carbonique
/
Amines
Langue:
En
Journal:
J Enzyme Inhib Med Chem
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2014
Type de document:
Article
Pays d'affiliation:
Turquie