An unusual cause of oesophageal variceal bleeding in a Chinese human immunodeficiency virus-infected patient.
Hong Kong Med J
; 19(1): 77-9, 2013 Feb.
Article
de En
| MEDLINE
| ID: mdl-23378360
ABSTRACT
Non-cirrhotic portal hypertension is an unusual but potentially serious liver disorder in human immunodeficiency virus-infected patients with prolonged exposure to didanosine. Due to its rarity, the diagnosis is often delayed. It is postulated that didanosine contributes to obliterative portal venopathy and causes portal hypertension. Affected patients may present with abnormal liver function or signs of portal hypertension, while the diagnosis usually depends on liver biopsy. We report a case of non-cirrhotic portal hypertension in a human immunodeficiency virus-infected patient. The reported histological features include nodular regenerative hyperplasia and hepatoportal sclerosis. Early recognition is important as timely management of severe portal hypertension may prevent potentially fatal gastro-intestinal bleeding.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Varices oesophagiennes et gastriques
/
Didéoxyinosine
/
Hémorragie gastro-intestinale
/
Hypertension portale
Type d'étude:
Diagnostic_studies
Limites:
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Hong Kong Med J
Sujet du journal:
MEDICINA
Année:
2013
Type de document:
Article
Pays d'affiliation:
Hong Kong