Connective tissue growth factor (CCN2) in blood vessels.
Vascul Pharmacol
; 58(3): 189-93, 2013 Mar.
Article
de En
| MEDLINE
| ID: mdl-23380714
ABSTRACT
The CCN family comprise the products of six immediate-early response genes (Cyr61, Ctgf, Nov and Wisp1-3) and are multi-functional proteins, characterised by four discrete protein modules in which reside functional domains an insulin-like growth factor binding protein-like module (IGFBP) but has low affinity for IGFBPs, a von Willebrand factor type C repeat module (VWC) which mediates integrin and growth factor binding, a thrombospondin type-1 repeat module (TSP-1), and a cysteine-knot-containing module (CT). These modules mediate a host of interactions such as growth factor binding, integrin recognition, and interaction(s) with heparin and proteoglycans (reviewed in Holbourn et al., 2008; Chen and Lau, 2009). The CCN family are involved in many normal and pathological cellular processes and have a plethora of functions including cell proliferation, angiogenesis, wound healing, and fibrogenesis, tumourigenesis. In addition, many roles have been described for CCN family members in the cardiovascular system (Table 1). The focus of this review is the role of connective tissue growth factor (CCN2, CTGF) in blood vessels and in vascular pathology.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Maladies vasculaires
/
Vaisseaux sanguins
/
Facteur de croissance du tissu conjonctif
Limites:
Animals
/
Humans
Langue:
En
Journal:
Vascul Pharmacol
Sujet du journal:
ANGIOLOGIA
/
FARMACOLOGIA
Année:
2013
Type de document:
Article
Pays d'affiliation:
Royaume-Uni