Perinatal xenohormone exposure impacts sweet preference and submandibular development in male rats.
Oral Dis
; 19(8): 812-23, 2013 Nov.
Article
de En
| MEDLINE
| ID: mdl-23410115
ABSTRACT
OBJECTIVE:
To determine the effect of perinatal exposure to low doses of genistein and/or vinclozolin on submandibular salivary gland (SSG) development in juvenile and adult male rats and to establish a link with sweet preference. MATERIAL ANDMETHODS:
Female rats received orally (1 mg kg(-1) body weight/day) genistein and vinclozolin, alone or in combination, from the first gestational day up to weaning. Sweet preference was assessed at weaning and in adulthood in male offspring; submandibular glands were then collected to study the morphogenesis and mRNA expression of steroid receptors, growth factors and taste related proteins.RESULTS:
Exposure to genistein and/or vinclozolin resulted in a higher saccharin intake on postnatal day 25 (P < 0.05) linked to a higher number of pro-acinar cells (P < 0.01) and mRNA expression of progesterone receptor, growth factors and gustine (P < 0.01). These increases disappeared in adulthood, but mRNA expressions of sex hormone receptors and growth factors were strongly repressed in all treated groups (P < 0.01).CONCLUSION:
Our findings confirm that the SSG are target for xenohormones and provide evidence that perinatal exposure to low doses of genistein and/or vinclozolin could simultaneously disrupt not only the salivary gland prepubertal development and sweet intake but also endocrine gene mRNA expression later in life.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Oxazoles
/
Saccharine
/
Glande submandibulaire
/
Goût
/
Génistéine
/
Phyto-oestrogènes
/
Préférences alimentaires
/
Antagonistes des androgènes
Aspects:
Patient_preference
Limites:
Animals
Langue:
En
Journal:
Oral Dis
Sujet du journal:
ODONTOLOGIA
Année:
2013
Type de document:
Article
Pays d'affiliation:
France