Longitudinal study of hormonal and physical development in young twins.
J Clin Endocrinol Metab
; 98(3): E518-27, 2013 Mar.
Article
de En
| MEDLINE
| ID: mdl-23430788
ABSTRACT
CONTEXT AND OBJECTIVE:
Information on the correlation of normative reproductive hormone levels with physical development (Tanner stages) during puberty and on the influences of genes and environment on variation in these hormones and Tanner stages is limited. DESIGN, SETTING, ANDPARTICIPANTS:
One hundred twelve healthy 9-year-old twin pairs (n = 224) took part in a longitudinal study, of which 89 pairs participated again at age 12 years (n = 178). MAIN OUTCOMEMEASURES:
Morning urinary LH, FSH, estradiol, and salivary testosterone levels, determined by competitive immunoassays, were measured. Tanner stages were determined through physical examination.RESULTS:
Over the 3-year interval, all hormone levels showed a 2- to 9-fold increase. LH and FSH at age 9 years predicted sex-specific Tanner stages at age 12 years in both boys and girls. Most of the associations between hormone levels at age 9 years and physical development at 12 years were explained by genetic influences. FSH in 9-year-old boys correlated with all hormone levels and Tanner stages at age 12 years. Moderate to high heritability estimates were found for hormone levels at both ages and in both sexes. In girls a shift from environmental (age 9 years) to genetic influences (age 12 years) was found for estradiol and pubic hair development, and for breast development a shift in the opposite direction was seen.CONCLUSIONS:
During development LH and FSH (and testosterone in boys) levels predict secondary sexual characteristics in boys and girls 3 years later. These correlations are largely due to genes that are involved in both early pubertal hormone levels and subsequent physical development.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Hormones sexuelles stéroïdiennes
/
Développement de l'enfant
/
Système endocrine
Type d'étude:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Child
/
Female
/
Humans
/
Male
Langue:
En
Journal:
J Clin Endocrinol Metab
Année:
2013
Type de document:
Article
Pays d'affiliation:
Pays-Bas