Contact investigation of a case of human novel coronavirus infection treated in a German hospital, October-November 2012.
Euro Surveill
; 18(8)2013 Feb 21.
Article
de En
| MEDLINE
| ID: mdl-23449231
ABSTRACT
On 24 October 2012, a patient with acute respiratory distress syndrome of unknown origin and symptom onset on 5 October was transferred from Qatar to a specialist lung clinic in Germany. Late diagnosis on 20 November of an infection with the novel Coronavirus (NCoV) resulted in potential exposure of a considerable number of healthcare workers. Using a questionnaire we asked 123 identified contacts (120 hospital and three out-of-hospital contacts) about exposure to the patient. Eighty-five contacts provided blood for a serological test using a two-stage approach with an initial immunofluorescence assay as screening test, followed by recombinant immunofluorescence assays and a NCoV-specific serum neutralisation test. Of 123 identified contacts nine had performed aerosol-generating procedures within the third or fourth week of illness, using personal protective equipment rarely or never, and two of these developed acute respiratory illness. Serology was negative for all nine. Further 76 hospital contacts also tested negative, including two sera initially reactive in the screening test. The contact investigation ruled out transmission to contacts after illness day 20. Our two-stage approach for serological testing may be used as a template for similar situations.
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Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
/
Traçage des contacts
/
Transmission de maladie infectieuse du patient au professionnel de santé
/
Infections à coronavirus
/
Coronavirus
Type d'étude:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Female
/
Humans
/
Male
/
Middle aged
Pays/Région comme sujet:
Asia
/
Europa
Langue:
En
Journal:
Euro Surveill
Sujet du journal:
DOENCAS TRANSMISSIVEIS
Année:
2013
Type de document:
Article
Pays d'affiliation:
Allemagne