Invariant Natural Killer T-cell anergy to endogenous myelin acetyl-glycolipids in multiple sclerosis.
J Neuroimmunol
; 259(1-2): 1-7, 2013 Jun 15.
Article
de En
| MEDLINE
| ID: mdl-23537888
ABSTRACT
To extend our studies on glycolipid-reactive invariant Natural Killer T-cell (iNKT-cell) function in multiple sclerosis (MS), we investigated the stimulatory activities of two myelin-derived glycolipids that are poly-acetylated derivatives of ß-galactosylceramide designated as fast-migrating cerebrosides (FMC) by thin-layer chromatography. In healthy subjects, FMC stimulation of peripheral blood cells significantly expanded iNKT-cells similar to α-GalCer and induced significant increases in Th1, Th2 and Th17 cytokines. In marked contrast, MS patients failed to respond to FMCs or to α-GalCer stimulation indicating an anergic response. We propose that myelin-derived FMC glycolipids stimulate iNKT-cell responses in vivo and this is blocked in MS.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Anergie clonale
/
Sclérose en plaques chronique progressive
/
Sclérose en plaques récurrente-rémittente
/
Cellules T tueuses naturelles
/
Galactosylcéramides
/
Gaine de myéline
Limites:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
J Neuroimmunol
Année:
2013
Type de document:
Article
Pays d'affiliation:
Irlande