Transmission of hepatitis E virus from rabbits to cynomolgus macaques.
Emerg Infect Dis
; 19(4): 559-65, 2013 Apr.
Article
de En
| MEDLINE
| ID: mdl-23628346
ABSTRACT
The recent discovery of hepatitis E virus (HEV) strains in rabbits in the People's Republic of China and the United States revealed that rabbits are another noteworthy reservoir of HEV. However, whether HEV from rabbits can infect humans is unclear. To study the zoonotic potential for and pathogenesis of rabbit HEV, we infected 2 cynomolgus macaques and 2 rabbits with an HEV strain from rabbits in China. Typical hepatitis developed in both monkeys; they exhibited elevated liver enzymes, viremia, virus shedding in fecal specimens, and seroconversion. Comparison of the complete genome sequence of HEV passed in the macaques with that of the inoculum showed 99.8% nucleotide identity. Rabbit HEV RNA (positive- and negative-stranded) was detectable in various tissues from the experimentally infected rabbits, indicating that extrahepatic replication may be common. Thus, HEV is transmissible from rabbits to cynomolgus macaques, which suggests that rabbits may be a new source of human HEV infection.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Lapins
/
Réservoirs de maladies
/
Virus de l'hépatite E
/
Hépatite E
/
Macaca fascicularis
Limites:
Animals
/
Humans
/
Male
Langue:
En
Journal:
Emerg Infect Dis
Sujet du journal:
DOENCAS TRANSMISSIVEIS
Année:
2013
Type de document:
Article