Determination of nitrogen mustard degradation products in water samples using a portable capillary electrophoresis instrument.
Electrophoresis
; 34(14): 2078-84, 2013 Jul.
Article
de En
| MEDLINE
| ID: mdl-23686627
ABSTRACT
In this work, a new purpose-made portable CE instrument with a contactless conductivity detector was used for the determination of degradation products of nitrogen mustards in different water samples. The capillary was coated with poly(1-vinylpyrrolidone-co-2-dimethylaminoethyl methacrylate) to avoid analyte-wall interactions. The coating procedure was studied to obtain the best repeatability of the migration time of the analytes. Four different coating procedures were compared; flushing the capillary with the copolymer at 100 psi for 2 min at 60°C provided the best RSD values (<4%). The analytical method was also optimized. The use of 20 mM of MES adjusted to pH 6.0 with His as running buffer allowed a good baseline separation of the three analytes in different water samples without matrix interferences. The method permitted the detection of the three degradation products down to 5 µM.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Polluants chimiques de l'eau
/
Armes chimiques
/
Électrophorèse capillaire
/
Chlorméthine
Type d'étude:
Evaluation_studies
Langue:
En
Journal:
Electrophoresis
Année:
2013
Type de document:
Article
Pays d'affiliation:
Espagne