Association of bone turnover markers with mortality in women referred to coronary angiography: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study.
Osteoporos Int
; 25(2): 455-65, 2014 Feb.
Article
de En
| MEDLINE
| ID: mdl-23775420
ABSTRACT
UNLABELLED We examined the association of fatal events with beta-crosslaps (ß-CTX) and osteocalcin (OC) concentrations in women. We observed an independent association of ß-CTX and OC concentrations with fatal events in women at high to intermediate cardiovascular risk. INTRODUCTION:
There is some evidence suggesting an association of ß-CTX and OC with fatal events in men and frail elderly subjects. We aimed to examine the association of fatal events with ß-CTX and OC in women.METHODS:
We measured ß-CTX and OC in 986 women aged 65 (58-72) years referred to coronary angiography.RESULTS:
Compared to the first ß-CTX quartile, the crude hazard ratios (HRs) for all-cause and cardiovascular mortality in the highest ß-CTX quartile were 2.50 (1.65-3.81) and 3.28 (1.82-5.91), respectively. In multivariate adjusted models, HRs for all-cause and cardiovascular mortality in the highest ß-CTX quartile were 1.72 (1.09-2.70) and 2.31 (1.24-4.32), respectively. The lowest 25-hydroxyvitamin D [25(OH)D] quartile was significantly associated with increased risk of all-cause and cardiovascular mortality in multivariate adjusted models. In those models, the highest ß-CTX quartile was associated with an increased risk of all-cause and cardiovascular mortality. For OC concentrations, we found a reverse J-shaped association with noncardiovascular mortality. Using the first quartile as reference, crude and multivariate adjusted HRs for noncardiovascular mortality in the second and third OC quartile were 0.41 (0.19-0.90) [multivariate 0.40 (0.18-0.88)] and 0.51 (0.25-1.06) [multivariate 0.43 (0.20-0.94)], respectively. The lowest 25(OH)D quartile was associated with a trend towards increased risk of noncardiovascular mortality in multivariate analysis. In that analysis, OC quartile 2 and 3 were significantly associated with lower risk of noncardiovascular mortality.CONCLUSIONS:
We observed an independent association of high ß-CTX with all-cause and cardiovascular mortality and a reverse J-shaped association of OC with noncardiovascular mortality.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Maladies cardiovasculaires
/
Ostéocalcine
/
Remodelage osseux
Type d'étude:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limites:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Pays/Région comme sujet:
Europa
Langue:
En
Journal:
Osteoporos Int
Sujet du journal:
METABOLISMO
/
ORTOPEDIA
Année:
2014
Type de document:
Article