The Golgi Apparatus: Panel Point of Cytosolic Ca(2+) Regulation.
Neurosignals
; 21(3-4): 272-84, 2013.
Article
de En
| MEDLINE
| ID: mdl-23796968
ABSTRACT
The Golgi apparatus (GA), an intermediate organelle of the cell inner membrane system, plays a key role in protein glycosylation and secretion. In recent years, this organelle has been found to act as a vital intracellular Ca(2+) store because different Ca (2+) regulators, such as the inositol-1,4,5-triphosphate receptor, sarco/endoplasmic reticulum Ca(2+) -ATPase and secretory pathway Ca 2+ -ATPase, were demonstrated to localize on their membrane. The mechanisms involved in Ca(2+) release and uptake in the GA have now been established.Here, based on careful backward looking on compartments and patterns in GA Ca (2+) regulation, we review neurological diseases related to GA calcium remodeling and propose a modified cytosolic Ca(2+) adjustment model, in which GA acts as part of the panel point.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Calcium
/
Signalisation calcique
/
Cytosol
/
Appareil de Golgi
Type d'étude:
Prognostic_studies
Limites:
Animals
/
Humans
Langue:
En
Journal:
Neurosignals
Sujet du journal:
NEUROLOGIA
Année:
2013
Type de document:
Article
Pays de publication:
CH
/
SUIZA
/
SUÍÇA
/
SWITZERLAND