Entrapment syndrome of multiple nerves in graft-versus-host disease.
Muscle Nerve
; 49(1): 138-42, 2014 Jan.
Article
de En
| MEDLINE
| ID: mdl-23893492
ABSTRACT
INTRODUCTION:
Peripheral nerve entrapment syndromes are associated with hereditary neuropathy with liability to pressure palsies and a variety of rheumatic and endocrinological diseases.METHODS:
We report a patient with entrapment syndromes of multiple nerves associated with chronic graft-versus-host-disease (GVHD) after allogeneic hematopoietic stem cell transplantation. Nerve ultrasound, histology, and ultrastructural changes were assessed.RESULTS:
The 51-year-old man had developed severe deep dermal sclerosis due to chronic GVHD with a progressive polyneuropathy and entrapment syndromes of multiple nerves. Pre-stenotic enlargement was shown by nerve ultrasound. Histology demonstrated fibrosis of the epineurium with scarce infiltration of macrophages. Electron microscopy demonstrated alterations of the myelin sheaths and marked depletion of normal-sized myelinated nerve fibers.CONCLUSIONS:
In addition to polyneuropathy, chronic GVHD can be associated with peripheral nerve entrapment syndromes and should be added to the differential diagnosis of compressive neuropathies.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Polyneuropathies
/
Maladie du greffon contre l'hôte
/
Syndromes de compression nerveuse
Type d'étude:
Diagnostic_studies
Limites:
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Muscle Nerve
Année:
2014
Type de document:
Article
Pays d'affiliation:
Allemagne