[Recent advances in study of neuroglobin expression in retinal diseases].

ABSTRACT

Neuroglobin (NGB) is widely exists in the retina and predominantly expressed in the plexiform layers and the inner segments. The physiological roles of NGB may include transportation of oxygen, protection against ischemia/hypoxia injury and oxidative stress, function as a redox-coupled sensor regulating the G-protein coupled transduction pathway, protection against neuronal apoptosis, and working as a terminal oxidase. Based on the function and distribution of NGB and the etiology and pathogenesis of retinal degeneration; it is possible that NGB may play a role in the development of retinal degeneration.