Long-term follow-up results of a multi-institutional phase 2 study of concurrent chemoradiation therapy for locally advanced cervical cancer in east and southeast Asia.
Int J Radiat Oncol Biol Phys
; 87(1): 100-5, 2013 Sep 01.
Article
de En
| MEDLINE
| ID: mdl-23920390
ABSTRACT
PURPOSE:
To report the long-term survival and toxicity of a multi-institutional phase 2 study of concurrent chemoradiation therapy (CCRT) for locally advanced cervical cancer in east and southeast Asia. METHODS AND MATERIALS Ten institutions from 8 Asian countries participated in the study. Between April 2003 and March 2006, 120 patients (60 with bulky stage IIB and 60 with stage IIIB) were treated with CCRT. Radiation therapy consisted of pelvic external beam radiation therapy and either high-dose-rate or low-dose-rate intracavitary brachytherapy. Five cycles of weekly cisplatin (40 mg/m(2)) were administered during the course of radiation therapy. Treatment results were evaluated by the rates of local control, overall survival, and late toxicities.RESULTS:
Median follow-up was 63.7 months, and the follow-up rate at 5 years was 98%. The 5-year local control and overall survival rates for all patients were 76.8% and 55.1%, respectively. The 5-year rates of major late toxicities of the rectum and bladder were 7.9% and 0%, respectively.CONCLUSIONS:
The long-term results have suggested that CCRT is safe and effective for patients with locally advanced cervical cancer in east and southeast Asia. However, further efforts are needed to improve overall survival.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs du col de l'utérus
/
Chimioradiothérapie
Type d'étude:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
Limites:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Pays/Région comme sujet:
Asia
Langue:
En
Journal:
Int J Radiat Oncol Biol Phys
Année:
2013
Type de document:
Article
Pays d'affiliation:
Japon