Prevention of Reg I-induced ß-cell apoptosis by IL-6/dexamethasone through activation of HGF gene regulation.

Nakagawa, Kei; Takasawa, Shin; Nata, Koji; Yamauchi, Akiyo; Itaya-Hironaka, Asako; Ota, Hiroyo; Yoshimoto, Kiyomi; Sakuramoto-Tsuchida, Sumiyo; Miyaoka, Tomoko; Takeda, Maiko; Unno, Michiaki; Okamoto, Hiroshi

Nakagawa, Kei; Takasawa, Shin; Nata, Koji; Yamauchi, Akiyo; Itaya-Hironaka, Asako; Ota, Hiroyo; Yoshimoto, Kiyomi; Sakuramoto-Tsuchida, Sumiyo; Miyaoka, Tomoko; Takeda, Maiko; Unno, Michiaki; Okamoto, Hiroshi.

Affiliation

Nakagawa K; Department of Advanced Biological Sciences for Regeneration (Kotobiken Medical Laboratories), Tohoku University Graduate School of Medicine, Sendai 980-8575, Miyagi, Japan; Department of Surgery, Tohoku University Graduate School of Medicine, Sendai 980-8575, Miyagi, Japan.
Takasawa S; Department of Advanced Biological Sciences for Regeneration (Kotobiken Medical Laboratories), Tohoku University Graduate School of Medicine, Sendai 980-8575, Miyagi, Japan; Department of Biochemistry, Nara Medical University, Kashihara 634-8521, Nara, Japan. Electronic address: shintksw@naramed-u.ac
Nata K; Department of Advanced Biological Sciences for Regeneration (Kotobiken Medical Laboratories), Tohoku University Graduate School of Medicine, Sendai 980-8575, Miyagi, Japan; Department of Medical Biochemistry, Iwate Medical University, School of Pharmacy, Yahaba 920-0293, Iwate, Japan.
Yamauchi A; Department of Biochemistry, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Itaya-Hironaka A; Department of Biochemistry, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Ota H; Department of Biochemistry, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Yoshimoto K; Department of Biochemistry, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Sakuramoto-Tsuchida S; Department of Biochemistry, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Miyaoka T; Department of Biochemistry, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Takeda M; Department of Biochemistry, Nara Medical University, Kashihara 634-8521, Nara, Japan.
Unno M; Department of Surgery, Tohoku University Graduate School of Medicine, Sendai 980-8575, Miyagi, Japan.
Okamoto H; Department of Advanced Biological Sciences for Regeneration (Kotobiken Medical Laboratories), Tohoku University Graduate School of Medicine, Sendai 980-8575, Miyagi, Japan; Tohoku University, Sendai 980-8577, Miyagi, Japan.

Biochim Biophys Acta ; 1833(12): 2988-2995, 2013 Dec.

Article de En | MEDLINE | ID: mdl-23954444

Sujet(s)
Mots clés

3-aminobenzamide; 3AB; 4[-3-(4-iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate; ChIP; Chromatin immunoprecipitation; Dx; FCS; GAPDH; GATA; Glucocorticoids; HGF; HGF gene; HSF-2; IL-6; NA; NOD mouse; Nrf-2; PARP; Pancreatic ß cell; RT-PCR; Reg; Reg protein; STAT; Transcriptional control; WST-1; dexamethasone; fetal calf serum; glyceraldehyde-3-phosphate dehydrogenase; heart shock factor 2; hepatocyte growth factor; interleukin-6; nicotinamide; non-obese diabetic mouse; nuclear respiratory factor 2; poly(ADP-ribose) polymerase; regenerating gene; reverse transcription polymerase chain reaction; signal transducer and activator of transcription; transcription factor

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Dexaméthasone / Régulation de l'expression des gènes / Interleukine-6 / Facteur de croissance des hépatocytes / Apoptose / Cellules à insuline / Lithostathine Limites: Animals / Humans / Male Langue: En Journal: Biochim Biophys Acta Année: 2013 Type de document: Article Pays d'affiliation: Japon Pays de publication: Pays-Bas

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