Heterocyclic glucocorticoid receptor modulators with a 2,2-dimethyl-3-phenyl-N-(thiazol or thiadiazol-2-yl)propanamide core.
Bioorg Med Chem Lett
; 23(20): 5571-4, 2013 Oct 15.
Article
de En
| MEDLINE
| ID: mdl-24011644
ABSTRACT
A series of heterocyclic glucocorticoid receptor (GR) modulators with 2,2-dimethyl-3-phenyl-N-(thiazol or thiadiazol-2-yl)propanamide core are described. Structure-activity relationships suggest a combination of H-bond acceptor and a 4-fluorophenyl moiety as being important structural components contributing to the glucocorticoid receptor binding and functional activity for this series of GR modulators.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Thiadiazoles
/
Thiazoles
/
Récepteurs aux glucocorticoïdes
/
Amides
/
Composés hétérocycliques
Langue:
En
Journal:
Bioorg Med Chem Lett
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2013
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique