HIV-1 accessory proteins: Vpu and Vif.
Methods Mol Biol
; 1087: 135-58, 2014.
Article
de En
| MEDLINE
| ID: mdl-24158820
ABSTRACT
HIV-1 Vif and Vpu are accessory factors involved in late stages of viral replication. Vif regulates viral infectivity by preventing virion incorporation of APOBEC3G and other members of the family of cytidine deaminases, while Vpu causes degradation of CD4 and promotes virus release by functionally inactivating the host factor BST-2. This chapter described techniques used for the characterization of Vif and Vpu and their functional interaction with host factors. Many of the techniques are, however, applicable to the functional analysis of other viral proteins.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
/
Produits du gène vif du virus de l'immunodéficience humaine
/
Protéines du virus de l'immunodéficience humaine
/
Protéines virales régulatrices ou accessoires
Limites:
Humans
Langue:
En
Journal:
Methods Mol Biol
Sujet du journal:
BIOLOGIA MOLECULAR
Année:
2014
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique