Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes.

Garside, Helen; Marcoe, Karen F; Chesnut-Speelman, Jessica; Foster, Alison J; Muthas, Daniel; Kenna, J Gerry; Warrior, Usha; Bowes, Joanne; Baumgartner, James

Garside, Helen; Marcoe, Karen F; Chesnut-Speelman, Jessica; Foster, Alison J; Muthas, Daniel; Kenna, J Gerry; Warrior, Usha; Bowes, Joanne; Baumgartner, James.

Affiliation

Garside H; AstraZeneca, Drug Safety and Metabolism, R&D, UK. Electronic address: helen.garside@astrazeneca.com.
Marcoe KF; Eurofins Panlabs Inc., USA. Electronic address: KarenMarcoe@eurofins.com.
Chesnut-Speelman J; Eurofins Panlabs Inc., USA.
Foster AJ; AstraZeneca, Drug Safety and Metabolism, R&D, UK.
Muthas D; AstraZeneca, Drug Safety and Metabolism, R&D, SE, Sweden.
Kenna JG; AstraZeneca, Drug Safety and Metabolism, R&D, UK.
Warrior U; Eurofins Panlabs Inc., USA.
Bowes J; AstraZeneca, Drug Safety and Metabolism, R&D, UK.
Baumgartner J; Eurofins Panlabs Inc., USA.

Toxicol In Vitro ; 28(2): 171-81, 2014 Mar.

Article de En | MEDLINE | ID: mdl-24189122

Sujet(s)
Mots clés

Hepatocytes; Hepatotoxicity; Imaging; Metabolism

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Hépatocytes / Lésions hépatiques dues aux substances Type d'étude: Diagnostic_studies Limites: Animals / Humans Langue: En Journal: Toxicol In Vitro Sujet du journal: TOXICOLOGIA Année: 2014 Type de document: Article Pays de publication: Royaume-Uni

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