Teaching NeuroImages: Ma2 encephalitis presenting as acute panhypopituitarism in a young man.
Neurology
; 81(19): e146-7, 2013 Nov 05.
Article
de En
| MEDLINE
| ID: mdl-24190004
ABSTRACT
A 21-year-old man presented with headache, hypotonia, hypothermia, and somnolence, deteriorating to a Glasgow Coma Scale score of 3 within days. Hormonal testing revealed panhypopituitarism. His cerebral MRI showed a gadolinium-enhancing lesion in the pituitary gland with adjacent changes to the hypothalamus, midbrain, and basal ganglia (figures 1 and 2). Therapy with prednisolone resulted in rapid improvement. Ma2 antibodies were found in the patient's serum and CSF. FDG-PET demonstrated a tumor mass in the superior mediastinum and histology revealed a mediastinal seminoma. Ma2 antibody-mediated paraneoplastic disease has to be considered as a rare differential diagnosis in patients presenting with acute panhypopituitarism.(1.)
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Encéphalite
/
Hypopituitarisme
/
Antigènes néoplasiques
/
Protéines de tissu nerveux
Type d'étude:
Diagnostic_studies
Limites:
Adult
/
Humans
/
Male
Langue:
En
Journal:
Neurology
Année:
2013
Type de document:
Article
Pays d'affiliation:
Allemagne