PEGylation improves the receptor-mediated transfection efficiency of peptide-targeted, self-assembling, anionic nanocomplexes.

Tagalakis, Aristides D; Kenny, Gavin D; Bienemann, Alison S; McCarthy, David; Munye, Mustafa M; Taylor, Hannah; Wyatt, Marcella J; Lythgoe, Mark F; White, Edward A; Hart, Stephen L

Tagalakis, Aristides D; Kenny, Gavin D; Bienemann, Alison S; McCarthy, David; Munye, Mustafa M; Taylor, Hannah; Wyatt, Marcella J; Lythgoe, Mark F; White, Edward A; Hart, Stephen L.

Affiliation

Tagalakis AD; Wolfson Centre for Gene Therapy of Childhood Disease, UCL Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK. Electronic address: a.tagalakis@ucl.ac.uk.
Kenny GD; Wolfson Centre for Gene Therapy of Childhood Disease, UCL Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.
Bienemann AS; Functional Neurosurgery Research Group, School of Clinical Sciences, AMBI Labs, University of Bristol, Southmead Hospital, Bristol BS10 5NB, UK.
McCarthy D; UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
Munye MM; Wolfson Centre for Gene Therapy of Childhood Disease, UCL Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.
Taylor H; Functional Neurosurgery Research Group, School of Clinical Sciences, AMBI Labs, University of Bristol, Southmead Hospital, Bristol BS10 5NB, UK.
Wyatt MJ; Functional Neurosurgery Research Group, School of Clinical Sciences, AMBI Labs, University of Bristol, Southmead Hospital, Bristol BS10 5NB, UK.
Lythgoe MF; UCL Centre for Advanced Biological Imaging, Division of Medicine and Institute of Child Health, University College London, 72 Huntley Street, London, WC1E 6DD, UK.
White EA; Functional Neurosurgery Research Group, School of Clinical Sciences, AMBI Labs, University of Bristol, Southmead Hospital, Bristol BS10 5NB, UK.
Hart SL; Wolfson Centre for Gene Therapy of Childhood Disease, UCL Institute of Child Health, University College London, 30 Guilford Street, London WC1N 1EH, UK.

J Control Release ; 174: 177-87, 2014 Jan 28.

Article de En | MEDLINE | ID: mdl-24269968

Sujet(s)
Mots clés

Anionic; Gene therapy; MRI; Nanoparticle; Self-assembling; Targeted

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Peptides / Polyéthylène glycols / ADN / Transfection / Nanoparticules Limites: Animals / Humans / Male Langue: En Journal: J Control Release Sujet du journal: FARMACOLOGIA Année: 2014 Type de document: Article Pays de publication: Pays-Bas

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