Ethanol induced acetylation of histone at G9a exon1 and G9a-mediated histone H3 dimethylation leads to neurodegeneration in neonatal mice.

Subbanna, S; Nagre, N N; Shivakumar, M; Umapathy, N S; Psychoyos, D; Basavarajappa, B S

Subbanna, S; Nagre, N N; Shivakumar, M; Umapathy, N S; Psychoyos, D; Basavarajappa, B S.

Affiliation

Subbanna S; Division of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
Nagre NN; Division of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
Shivakumar M; Division of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA.
Umapathy NS; Vascular Biology Center, Georgia Regents University, Augusta, GA 30912, USA.
Psychoyos D; Institute of Biosciences and Technology, Houston, Texas A&M University Health Science Center, Houston, TX 77030, USA.
Basavarajappa BS; Division of Analytical Psychopharmacology, Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA; New York State Psychiatric Institute, College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA; Department of Psychiatry, College of Physicians & Surge

Neuroscience ; 258: 422-32, 2014 Jan 31.

Article de En | MEDLINE | ID: mdl-24300108

Sujet(s)
Mots clés

ANOVA; BELs; CC3; ChIP; DNA methyltransferase; DNMT3A; FASD; G9a-related protein; GLP; H3K27me2; H3K9me2; IPs; MeCP2; analysis of variance; apoptosis; blood ethanol levels; cDNA; cTau; caspase 3-cleaved-tau; chromatin immunoprecipitation; cleaved caspase-3 (Asp175); complementary DNA; development; epigenetic; histone H3 lysine 27; histone H3 lysine 9; hprt; hypoxanthinephophoribosyltransferase; immunoprecipitates; methyl-CpG-binding protein 2; qPCR; quantitative real-time polymerase chain reaction

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Histone / Dépresseurs du système nerveux central / Histone-lysine N-methyltransferase / Maladies neurodégénératives / Éthanol Limites: Animals Langue: En Journal: Neuroscience Année: 2014 Type de document: Article Pays d'affiliation: États-Unis d'Amérique

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