Three pairs of variecolortide enantiomers from Eurotium sp. with caspase-3 inhibitory activity.
Fitoterapia
; 92: 252-9, 2014 Jan.
Article
de En
| MEDLINE
| ID: mdl-24321580
ABSTRACT
7-O-methylvariecolortide A (1), variecolortide B (2), and variecolortide C (3), the rare variecolortides existing in racemic manner, were isolated from an endolichenic fungal strain Eurotium sp. (No. 17-11-8-1). With the chiral HPLC technology, (-)-(S)-7-O-methylvariecolortide A (1a), (+)-(R)-7-O-methylvariecolortide A (1b), (-)-(S)-variecolortide B (2a), (+)-(R)-variecolortide B (2b), (-)-(S)-variecolortide C (3a), and (+)-(R)-variecolortide C (3b) were successfully separated and obtained. Their absolute configurations were firstly assigned by ECD experiment and ECD calculation. According to the relation of isolated compounds, a plausible biosynthetic pathway for variecolortides was proposed. In caspase-3 enzymatic assay, compounds 1-3 showed inhibitory activity, with IC50 values of 1.7, 0.8 and 15.7 µM, respectively.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Pipérazines
/
Produits biologiques
/
Antienzymes
/
Caspase-3
/
Eurotium
/
Anthracènes
Langue:
En
Journal:
Fitoterapia
Année:
2014
Type de document:
Article