Effect of oral anticoagulants on the outcome of faecal immunochemical test.
Br J Cancer
; 110(5): 1334-7, 2014 Mar 04.
Article
de En
| MEDLINE
| ID: mdl-24496455
ABSTRACT
BACKGROUND:
We aimed to evaluate whether oral anticoagulants (OACs) alter faecal immunochemical test (FIT) performance in average-risk colorectal cancer (CRC) screening.METHODS:
Individuals aged 50-69 years were invited to receive one FIT sample (cutoff 75 ng ml(-1)) between November 2008 and June 2011.RESULTS:
Faecal immunochemical test was positive in 9.3% (21 out of 224) of users of OAC and 6.2% (365 out of 5821) of non-users (P-trend=0.07). The positive predictive value (PPV) for advanced neoplasia (AN) in non-users was 50.4% vs 47.6% in users (odds ratio, 0.70; 95% CI, 0.3-1.8; P=0.5). The PPV for AN in OAC more antiplatelets (aspirin or clopidogrel) was 75% (odds ratio, 2; 95% CI, 0.4-10.8; P=0.4).CONCLUSIONS:
Oral anticoagulant did not significantly modify the PPV for AN in this population-based colorectal screening program. The detection rate of advanced adenoma was higher in the combination OAC more antiplatelets.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Tumeurs colorectales
/
Anticoagulants
/
Sang occulte
Type d'étude:
Clinical_trials
/
Diagnostic_studies
/
Prognostic_studies
/
Screening_studies
Limites:
Female
/
Humans
/
Male
/
Middle aged
Langue:
En
Journal:
Br J Cancer
Année:
2014
Type de document:
Article
Pays d'affiliation:
Espagne