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Optimization of plasmepsin inhibitor by focusing on similar structural feature with chloroquine to avoid drug-resistant mechanism of Plasmodium falciparum.
Miura, Takuya; Hidaka, Koushi; Azai, Yukiko; Kashimoto, Keisuke; Kawasaki, Yuko; Chen, Shen-En; de Freitas, Renato Ferreira; Freire, Ernesto; Kiso, Yoshiaki.
Affiliation
  • Miura T; Center for Frontier Research in Medicinal Science, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.
  • Hidaka K; Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Chuo-ku, Kobe 650-8586, Japan.
  • Azai Y; Center for Frontier Research in Medicinal Science, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.
  • Kashimoto K; Center for Frontier Research in Medicinal Science, Kyoto Pharmaceutical University, Yamashina-ku, Kyoto 607-8412, Japan.
  • Kawasaki Y; Department of Biology and Johns Hopkins Malaria Research Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Chen SE; Department of Biology and Johns Hopkins Malaria Research Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
  • de Freitas RF; Department of Biology and Johns Hopkins Malaria Research Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Freire E; Department of Biology and Johns Hopkins Malaria Research Institute, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Kiso Y; Laboratory of Peptide Science, Nagahama Institute of Bio-Science and Technology, Nagahama, Shiga 526-0829, Japan. Electronic address: y_kiso@nagahama-i-bio.ac.jp.
Bioorg Med Chem Lett ; 24(7): 1698-701, 2014 Apr 01.
Article de En | MEDLINE | ID: mdl-24631188
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Plasmodium falciparum / Inhibiteurs de protéases / Chloroquine / Aspartic acid endopeptidases / Multirésistance aux médicaments / Antipaludiques Langue: En Journal: Bioorg Med Chem Lett Sujet du journal: BIOQUIMICA / QUIMICA Année: 2014 Type de document: Article Pays d'affiliation: Japon Pays de publication: Royaume-Uni
Texte intégral
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XML
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Plasmodium falciparum / Inhibiteurs de protéases / Chloroquine / Aspartic acid endopeptidases / Multirésistance aux médicaments / Antipaludiques Langue: En Journal: Bioorg Med Chem Lett Sujet du journal: BIOQUIMICA / QUIMICA Année: 2014 Type de document: Article Pays d'affiliation: Japon Pays de publication: Royaume-Uni