Temporalis muscle hypertrophy and reduced skull eccentricity in Duchenne muscular dystrophy.
J Child Neurol
; 29(10): 1344-8, 2014 Oct.
Article
de En
| MEDLINE
| ID: mdl-24646504
ABSTRACT
Muscle hypertrophy and muscle weakness are well known in Duchenne muscular dystrophy. Decreased muscle force can have secondary effects on skeletal growth and development such as facial and dental morphology changes. In this study, we quantified temporal muscle thickness, circumference, and eccentricity of the skull and the head on T1-weighted magnetic resonance imaging (MRI) scans of the head of 15 Duchenne muscular dystrophy patients and 15 controls. Average temporal muscle thickness was significantly increased in patients (12.9 ± 5.2 mm) compared to controls (6.8 ± 1.4 mm) (P < .0001), whereas the shape of the skull was significantly rounder compared to controls. Temporal muscle thickness and skull eccentricity were significantly negatively correlated in patients, and positively in controls. Hypertrophy of the temporal muscles and changes in skull eccentricity appear to occur early in the course of Duchenne muscular dystrophy. Further studies in younger patients are needed to confirm a causal relationship.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Crâne
/
Muscle temporal
/
Myopathie de Duchenne
Limites:
Adolescent
/
Child
/
Humans
/
Male
Langue:
En
Journal:
J Child Neurol
Sujet du journal:
NEUROLOGIA
/
PEDIATRIA
Année:
2014
Type de document:
Article
Pays d'affiliation:
Pays-Bas