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Biochemical, cellular, and biophysical characterization of a potent inhibitor of mutant isocitrate dehydrogenase IDH1.
Davis, Mindy I; Gross, Stefan; Shen, Min; Straley, Kimberly S; Pragani, Rajan; Lea, Wendy A; Popovici-Muller, Janeta; DeLaBarre, Byron; Artin, Erin; Thorne, Natasha; Auld, Douglas S; Li, Zhuyin; Dang, Lenny; Boxer, Matthew B; Simeonov, Anton.
Affiliation
  • Davis MI; From the NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20892.
  • Gross S; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, and.
  • Shen M; From the NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20892.
  • Straley KS; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, and.
  • Pragani R; From the NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20892.
  • Lea WA; From the NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20892.
  • Popovici-Muller J; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, and.
  • DeLaBarre B; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, and.
  • Artin E; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, and.
  • Thorne N; From the NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20892.
  • Auld DS; From the NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20892, the Center for Proteomic Chemistry, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts 02139.
  • Li Z; From the NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20892.
  • Dang L; Agios Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, and.
  • Boxer MB; From the NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20892.
  • Simeonov A; From the NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20892, asimeono@mail.nih.gov.
J Biol Chem ; 289(20): 13717-25, 2014 May 16.
Article de En | MEDLINE | ID: mdl-24668804
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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Benzimidazoles / Antienzymes / Protéines mutantes / Phénomènes biophysiques / Isocitrate dehydrogenases / Acétamides / Mutation Limites: Animals / Humans Langue: En Journal: J Biol Chem Année: 2014 Type de document: Article
Texte intégral
Ajouter à My VHL
Imprimer
XML
PubMed Links
Recherche sur Google

Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Benzimidazoles / Antienzymes / Protéines mutantes / Phénomènes biophysiques / Isocitrate dehydrogenases / Acétamides / Mutation Limites: Animals / Humans Langue: En Journal: J Biol Chem Année: 2014 Type de document: Article