Comparison of transepithelial corneal collagen crosslinking with epithelium-off crosslinking in progressive keratoconus.
J Fr Ophtalmol
; 37(5): 371-6, 2014 May.
Article
de En
| MEDLINE
| ID: mdl-24679451
ABSTRACT
PURPOSE:
To evaluate the safety and efficacy of transepithelial corneal collagen crosslinking (TE-CXL) as compared to epithelium-off crosslinking (epi-off CXL) in progressive keratoconus.METHODS:
Records of keratoconus patients treated with TE-CXL or epi-off CXL were reviewed retrospectively. Patients were included if they had at least 12months follow-up. Pre- and postoperative measurements of visual acuity, refractive errors, keratometry, corneal topography and pachymetry were assessed and compared.RESULTS:
There was no statistically significant difference between two groups at baseline in terms of demographic, refractive and corneal parameters. Mean maximum cone apex curvature (apical K) increased from 51.62±5. Eighty-four diopters (D) to 53.70±5.49 D in the TE-CXL group (n=17), and decreased from 52.02±4.07 D to 51.22±3.51 in the epi-off CXL group (n=19) at the end of the follow-up period. The difference between two groups was statistically significant (P=0.0002). An increase of≥1D in apical K was observed in two of 19 eyes (11%) in the epi-off CXL group, and 11 of 17 eyes (65%) in TE-CXL group at the last follow-up visit, compared to baseline (P<0.0001). Fourteen patients in the epi-off CXL group exhibited corneal edema that resolved without haze with topical corticosteroid treatment by 4months. No postoperative corneal edema was observed in TE-CXL group.CONCLUSIONS:
Although it is safe and well tolerated, TE-CXL does not effectively halt the progression of keratoconus. Epi-off CXL appears to be effective in stopping progression and even improves corneal parameters.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Photothérapie dynamique
/
Collagène
/
Épithélium antérieur de la cornée
/
Cornée
/
Réactifs réticulants
/
Kératocône
Type d'étude:
Evaluation_studies
Limites:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Langue:
En
Journal:
J Fr Ophtalmol
Année:
2014
Type de document:
Article
Pays d'affiliation:
Turquie