[Severe hypercalcemia revealing sarcoidosis precipitated by etanercept]. / Hypercalcémie majeure révélatrice d'une sarcoïdose induite par étanercept.
Rev Mal Respir
; 31(3): 255-8, 2014 Mar.
Article
de Fr
| MEDLINE
| ID: mdl-24680117
ABSTRACT
INTRODUCTION:
The principal secondary effects of anti-TNF alpha therapy are now well understood, particularly the risk of opportunistic infections. Other paradoxical effects have been described much more occasionally such as the developement of sarcoid-like granulomatous reactions. CASE REPORT We report here the case of a woman of 39 years treated for severe rheumatoid arthritis for five years with etanercept. She was admitted to hospital as an emergency with vomiting and diffuse abdominal pain. Investigations revealed severe hypercalcaemia and acute renal failure. After correction of the metabolic disturbances with rehydration and biphosphonates, CT scanning of the abdomen, pelvis and thorax showed bilateral interstitial infiltration and splenomegaly. The diagnosis of sarcoidosis was confirmed by endoscopic bronchial biopsies. Progress was satisfactory following withdrawal of the etanercept and corticosteroid therapy in reducing dosage.CONCLUSION:
The risk of induced sarcoidosis should be understood in patients receiving anti-TNF therapy and should be considered in cases of hypercalcaemia and/or splenomegaly.Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Sarcoïdose
/
Immunoglobuline G
/
Antirhumatismaux
/
Hypercalcémie
Type d'étude:
Etiology_studies
Limites:
Adult
/
Female
/
Humans
Langue:
Fr
Journal:
Rev Mal Respir
Année:
2014
Type de document:
Article
Pays d'affiliation:
France