A hypothesis: hydrogen sulfide might be neuroprotective against subarachnoid hemorrhage induced brain injury.
ScientificWorldJournal
; 2014: 432318, 2014.
Article
de En
| MEDLINE
| ID: mdl-24707204
ABSTRACT
Gases such as nitric oxide (NO) and carbon monoxide (CO) play important roles both in normal physiology and in disease. Recent studies have shown that hydrogen sulfide (H2S) protects neurons against oxidative stress and ischemia-reperfusion injury and attenuates lipopolysaccharides (LPS) induced neuroinflammation in microglia, exhibiting anti-inflammatory and antiapoptotic activities. The gas H2S is emerging as a novel regulator of important physiologic functions such as arterial diameter, blood flow, and leukocyte adhesion. It has been known that multiple factors, including oxidative stress, free radicals, and neuronal nitric oxide synthesis as well as abnormal inflammatory responses, are involved in the mechanism underlying the brain injury after subarachnoid hemorrhage (SAH). Based on the multiple physiologic functions of H2S, we speculate that it might be a promising, effective, and specific therapy for brain injury after SAH.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Hémorragie meningée
/
Lésions encéphaliques
/
Neuroprotecteurs
/
Sulfure d'hydrogène
Type d'étude:
Etiology_studies
Limites:
Animals
/
Humans
Langue:
En
Journal:
ScientificWorldJournal
Sujet du journal:
MEDICINA
Année:
2014
Type de document:
Article
Pays d'affiliation:
Chine