A 5000-fold increase in the specificity of a bacterial phosphotriesterase for malathion through combinatorial active site mutagenesis.

Naqvi, Tatheer; Warden, Andrew C; French, Nigel; Sugrue, Elena; Carr, Paul D; Jackson, Colin J; Scott, Colin

Naqvi, Tatheer; Warden, Andrew C; French, Nigel; Sugrue, Elena; Carr, Paul D; Jackson, Colin J; Scott, Colin.

Affiliation

Naqvi T; Department of Environmental Sciences, COMSATS Institute of Information Technology, Abbottabad, Pakistan; Ecosystem Sciences, Commonwealth Scientific and Industrial Research Organisation, Canberra, Australian Capital Territory, Australia.
Warden AC; Ecosystem Sciences, Commonwealth Scientific and Industrial Research Organisation, Canberra, Australian Capital Territory, Australia.
French N; Ecosystem Sciences, Commonwealth Scientific and Industrial Research Organisation, Canberra, Australian Capital Territory, Australia.
Sugrue E; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia.
Carr PD; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia.
Jackson CJ; Research School of Chemistry, Australian National University, Canberra, Australian Capital Territory, Australia.
Scott C; Ecosystem Sciences, Commonwealth Scientific and Industrial Research Organisation, Canberra, Australian Capital Territory, Australia.

PLoS One ; 9(4): e94177, 2014.

Article de En | MEDLINE | ID: mdl-24721933

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Ingénierie des protéines / Mutagenèse / Phosphoric triester hydrolases / Malathion Langue: En Journal: PLoS One Sujet du journal: CIENCIA / MEDICINA Année: 2014 Type de document: Article Pays d'affiliation: Australie Pays de publication: États-Unis d'Amérique

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