Polymorphism of DC-SIGN (CD209) promoter in association with clinical symptoms of dengue fever.
Viral Immunol
; 27(5): 245-9, 2014 Jun.
Article
de En
| MEDLINE
| ID: mdl-24797508
ABSTRACT
C-type lectin DC-SIGN receptor, encoded by CD209, plays a key role in the infection of dendritic cells by dengue virus (DENV). Because the -336A/G SNP (rs4804803) polymorphism in the promoter of CD209 modulates DC-SIGN expression, we investigated the putative association of this polymorphism with DENV infection and its pathogenesis. A control sample of 72 individuals, rigorously selected through a clinical investigation for absence of past dengue fever (DF) was compared to a sample of 168 patients (156 classical DF; 12 dengue hemorrhagic fever), all residents from Pará, Brazil. However, the prevalence of symptoms showed a trend higher in the AA genotype (Wilcoxon test; Z=2.02; p=0.04). Hence, our findings indicate that the G allele downregulates the spectrum of symptoms during the early acute phase of DENV infection, putatively decreasing the viremia, as suggested in the literature.
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Polymorphisme génétique
/
Molécules d'adhérence cellulaire
/
Régions promotrices (génétique)
/
Récepteurs de surface cellulaire
/
Dengue
/
Lectines de type C
Type d'étude:
Diagnostic_studies
/
Observational_studies
/
Risk_factors_studies
Limites:
Adult
/
Female
/
Humans
/
Male
Pays/Région comme sujet:
America do sul
/
Brasil
Langue:
En
Journal:
Viral Immunol
Sujet du journal:
ALERGIA E IMUNOLOGIA
/
VIROLOGIA
Année:
2014
Type de document:
Article
Pays d'affiliation:
Brésil