Removing T-cell epitopes with computational protein design.

King, Chris; Garza, Esteban N; Mazor, Ronit; Linehan, Jonathan L; Pastan, Ira; Pepper, Marion; Baker, David

King, Chris; Garza, Esteban N; Mazor, Ronit; Linehan, Jonathan L; Pastan, Ira; Pepper, Marion; Baker, David.

Affiliation

King C; Institute for Protein Design, Department of Biochemistry and chrisk1@uw.edu.
Garza EN; Department of Immunology, University of Washington, Seattle, WA 98195; and.
Mazor R; National Cancer Institute and.
Linehan JL; National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, MD 20892.
Pastan I; National Cancer Institute and.
Pepper M; Department of Immunology, University of Washington, Seattle, WA 98195; and.
Baker D; Institute for Protein Design, Department of Biochemistry and.

Proc Natl Acad Sci U S A ; 111(23): 8577-82, 2014 Jun 10.

Article de En | MEDLINE | ID: mdl-24843166

Sujet(s)
Mots clés

Rosetta; biotherapeutics; deimmunization; immunotoxin; machine learning

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Texte intégral: 1 Collection: 01-internacional Base de données: MEDLINE Sujet principal: Ingénierie des protéines / Protéines / Immunotoxines / Déterminants antigéniques des lymphocytes T Type d'étude: Prognostic_studies Langue: En Journal: Proc Natl Acad Sci U S A Année: 2014 Type de document: Article Pays de publication: États-Unis d'Amérique

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