Aryl-substituted aminobenzimidazoles targeting the hepatitis C virus internal ribosome entry site.
Bioorg Med Chem Lett
; 24(14): 3113-7, 2014 Jul 15.
Article
de En
| MEDLINE
| ID: mdl-24856063
ABSTRACT
We describe the exploration of N1-aryl-substituted benzimidazoles as ligands for the hepatitis C virus (HCV) internal ribosome entry site (IRES) RNA. The design of the compounds was guided by the co-crystal structure of a benzimidazole viral translation inhibitor in complex with the RNA target. Structure-binding activity relationships of aryl-substituted benzimidazole ligands were established that were consistent with the crystal structure of the translation inhibitor complex.
Mots clés
Texte intégral:
1
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Antiviraux
/
Ribosomes
/
Benzimidazoles
/
ARN viral
/
Hepacivirus
Langue:
En
Journal:
Bioorg Med Chem Lett
Sujet du journal:
BIOQUIMICA
/
QUIMICA
Année:
2014
Type de document:
Article
Pays d'affiliation:
États-Unis d'Amérique