ETAS, an enzyme-treated asparagus extract, attenuates amyloid beta-induced cellular disorder in PC12 cells.
Nat Prod Commun
; 9(4): 561-4, 2014 Apr.
Article
de En
| MEDLINE
| ID: mdl-24868884
One of the pathological characterizations of Alzheimer's disease (AD) is the deposition of amyloid beta peptide (Abeta) in cerebral cortical cells. The deposition of Abeta in neuronal cells leads to an increase in the production of free radicals that are typified by reactive oxygen species (ROS), thereby inducing cell death. A growing body of evidence now suggests that several plant-derived food ingredients are capable of scavenging ROS in mammalian cells. The purpose of the present study was to investigate whether enzyme-treated asparagus extract (ETAS), which is rich in antioxidants, is one of these ingredients. The pre-incubation of differentiated PC 12 cells with ETAS significantly recovered Abeta-induced reduction of cell viability, which was accompanied by reduced levels of ROS. These results suggest that ETAS may be one of the functional food ingredients with anti-oxidative capacity to help prevent AD.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Extraits de plantes
/
Peptides bêta-amyloïdes
/
Asparagus
Limites:
Animals
Langue:
En
Journal:
Nat Prod Commun
Sujet du journal:
BOTANICA
/
FARMACOLOGIA
/
QUIMICA
Année:
2014
Type de document:
Article
Pays de publication:
États-Unis d'Amérique