Omega-3 PUFAs induce apoptosis of gastric cancer cells via ADORA1.
Front Biosci (Landmark Ed)
; 19(6): 854-61, 2014 06 01.
Article
de En
| MEDLINE
| ID: mdl-24896321
ABSTRACT
Omega-3 polyunsaturated fatty acids (Omega-3 PUFAs), including docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), have been suggested to have anti-cancer effects by epidemiological and clinical studies. However, their underlying anti-cancer mechanisms are still unclear. In this study, we examined the influence of two Omega-3 PUFAs (DHA and EPA) on the proliferation and apoptosis of gastric cancer (GC) cells, and found that DHA and EPA reduced the viability of GC cells and induced apoptosis by activating caspase-3. Moreover, we screened the expression profile of apoptosis-related genes in GC cells upon the treatment of DHA and/or EPA, and discovered that ADORA1, one subtype of adenosine receptor functionally involved in cell death, was up-regulated in response to DHA and EPA. Importantly, when GC cells were treated with a selective ADORA1 antagonist, DPCPX, the DHA/EPA-induced apoptosis was substantially reduced. Taken together, our results suggest that the anti-cancer effect of Omega-3 PUFAs on gastric cancer is at least partly dependent on activating the ADORA1-mediated apoptosis pathway.
Recherche sur Google
Collection:
01-internacional
Base de données:
MEDLINE
Sujet principal:
Acides gras omega-3
/
Régulation de l'expression des gènes tumoraux
/
Apoptose
/
Récepteur A1 à l'adénosine
Limites:
Humans
Langue:
En
Journal:
Front Biosci (Landmark Ed)
Année:
2014
Type de document:
Article
Pays d'affiliation:
Chine